Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation
نویسندگان
چکیده
منابع مشابه
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiation.
Inactivation of Lrp5, a gene encoding a likely Wnt co-receptor, results in low bone mass (osteopenia) by decreasing bone formation, suggesting that Wnt signaling in osteoblasts regulates bone formation. Here we show that Tcf1 and Tcf4 are expressed in osteoblasts during development and after birth; stabilization of beta-catenin, an essential component of canonical Wnt signaling, in differentiat...
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Mesenchymal cells alter and retain their phenotype during skeletal development through activation or suppression of signaling pathways. For example, we have shown that Wnt3a only stimulates osteoblast differentiation in cells with intrinsic osteogenic potential (e.g., MC3T3-E1 preosteoblasts) and not in fat cell precursors or fibroblasts (respectively, 3T3-L1 preadipocytes or NIH3T3 fibroblasts...
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Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate oste...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2005
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2005.02.017